NAD+
Cellular energy, focus, and metabolic support
Educational content, not medical advice. All prescribing decisions are made by a U.S. licensed clinician after intake.
What NAD+ is
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme every cell uses to convert food into usable energy and to run DNA repair. Levels decline with age, which is why NAD+ has become one of the most requested longevity protocols.
What it's used for
- Supports mitochondrial energy production
- Commonly reported improvements in mental clarity and daytime energy
- Involved in DNA repair and cellular stress response pathways
- Injection avoids the absorption losses of oral precursors
How the protocol runs
Who it tends to suit
- Adults with persistent low energy despite decent sleep
- People stacking a longevity protocol with hormone or peptide therapy
- Anyone who found oral NAD precursors underwhelming
What to know first
- Injections are commonly reported to cause a flushing or 'wave' sensation if pushed too fast — dose is escalated gradually for that reason.
- Long-term human outcome data on supplemental NAD+ is still developing.
- NAD+ is not a stimulant and will not compensate for chronic sleep debt.
Frequently asked questions
What does NAD+ actually do?
It is a coenzyme required for the reactions that turn nutrients into cellular energy, and it is a substrate for repair enzymes such as sirtuins and PARPs. Levels fall with age, which is the rationale behind supplementation.
Is injectable NAD+ better than oral NMN or NR?
Injection bypasses first-pass metabolism, so more reaches circulation than with oral precursors. Whether that translates into better outcomes is still being studied, but subjectively most patients report a clearer effect from injections.
How often do I inject?
Most protocols start weekly at a low dose and increase gradually based on tolerance. Your clinician sets the schedule after intake.
Related protocols
See if NAD+ fits your plan
Take the 3-minute intake. A licensed clinician reviews your answers and builds a protocol around your goals — no obligation.